DINO-Mix: Distilling Foundational Knowledge with Cross-Domain CutMix for Semi-supervised Class-imbalanced Medical Image Segmentation

Abstract

Semi-supervised learning (SSL) has emerged as a critical paradigm for medical image segmentation, mitigating the immense cost of dense annotations. However, prevailing SSL frameworks are fundamentally "inward-looking", recycling information and biases solely from within the target dataset. This design triggers a vicious cycle of confirmation bias under class imbalance, leading to the catastrophic failure to recognize minority classes. To dismantle this systemic issue, we propose a paradigm shift to a multi-level "outward-looking" framework. Our primary innovation is Foundational Knowledge Distillation (FKD), which looks outward beyond the confines of medical imaging by introducing a pre-trained visual foundation model, DINOv3, as an unbiased external semantic teacher. Instead of trusting the student's biased high confidence, our method distills knowledge from DINOv3's robust understanding of high semantic uniqueness, providing a stable, cross-domain supervisory signal that anchors the learning of minority classes. To complement this core strategy, we further look outward within the data by proposing Progressive Imbalance-aware CutMix (PIC), which creates a dynamic curriculum that adaptively forces the model to focus on minority classes in both labeled and unlabeled subsets. This layered strategy forms our framework, DINO-Mix, which breaks the vicious cycle of bias and achieves remarkable performance on challenging semi-supervised class-imbalanced medical image segmentation benchmarks Synapse and AMOS.