Conductive Scaffolding for Neural Tissue Regeneration: 3D Bridging with Two-Photon Fabrication

Abstract

We report on a novel dual-structure scaffold fabricated using two-photon polymerisation (2PP), integrating electrically conductive and non-conductive regions within a single architecture, targeting neural tissue regeneration. Poly(ethylene glycol) diacrylate (PEGDA) was combined with 20 nm gold nanoparticles to create a conductive microstructure, encapsulated within a biocompatible PEGDA lattice designed to support neuronal growth possibility after neural injuries. Electrical resistance measurements confirmed the feasibility of integrating conductive pathways into precision-fabricated microarchitectures.

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