In-vivo entropy production of A. subaru

Abstract

Entropy production is often used as a proxy for energy consumption of a non-equilibrium system. Lower bounds can be estimated from coarse-grained observations, and this has been done for various biological systems. Here, we apply these tools to a more macroscopic system whose true energy consumption is also known. We find that while entropy production does give a lower bound, it is some 25 orders of magnitude away from being saturated. To be certain of this result, we survey different methods of estimating irreversibility, and write down a novel kNN estimator.