Real time monitoring of pressure-induced deformation of PDMS to evaluate pressure distribution in microfluidic channels

Abstract

Accurate pressure measurements in micrometric channels are essential for a wide range of microfluidic applications. Existing approaches rely on a variety of sensing mechanisms, but generally require the integration of additional probes or sensing elements during or after chip fabrication. Here, we introduce a pressure sensing approach based on quantitative phase imaging of the deformation of compliant microfluidic channels. We demonstrate real-time measurements of channel deformation over a large field of view with high sensitivity, without the need for embedded components or modifications of the microfluidic device.