RRP-Voice: A Longitudinal Dataset and Benchmark for Recurrent Respiratory Papillomatosis Detection

Abstract

Deep learning has advanced pathological voice detection rapidly, yet rare laryngeal diseases remain underexplored due to data scarcity. Recurrent Respiratory Papillomatosis (RRP) exemplifies this gap: an HPV-induced disease of the larynx in which patients oscillate between recurrence and post-surgical remission over the years. RRP demands continuous voice monitoring that existing cross-sectional corpora cannot support. We introduce the first longitudinal voice dataset for RRP, comprising recordings from 26 patients with up to ten years of follow-up. Each session pairs sustained vowels with sentence-level utterances, which are annotated by otolaryngologists and confirmed synchronously with laryngoscopy. Building on this resource, we establish a systematic benchmark spanning handcrafted features, end-to-end deep networks, self-supervised pretrained models, and recent audio large language models, all evaluated under session-level cross-validation with patient-level audit. Per-subject longitudinal analyses further confirm that the cross-sectional discriminative signal reflects laryngoscopic disease state rather than stable speaker attributes. This work lays a foundation for rare longitudinal pathological voice tasks in low-resource clinical settings.