Creativity in the BioFoundry: Supporting scientific creativity in the age of automation

Abstract

Biofoundries automate biological experimentation at unprecedented scale, promising speed, reproducibility, and access. Yet automation also reshapes how scientists experience experimentation and creativity. Through in-depth interviews with nine scientists and experts across academia and industry (including biofoundry developers, automation engineers, and end-users), we examine how scientific creativity is enacted under automation. Biofoundries displace sensory cues, redistribute responsibility between humans and machines, and transform troubleshooting from an embodied, local practice into a predictive, social, and interpretive one. Rather than framing biofoundries as automation factories, we argue that they should be understood as Creativity Support Tools, whose design directly shapes how researchers notice breakdowns, exercise judgment, learn from failure, and progress through success. By connecting biofoundry practice with prior HCI work on automation, debugging, and distributed creativity, this paper demonstrates biofoundries as a distinctive and timely site for creativity research in science.