Quantifying Entrainment Evidence: A Comparison of Frequentist and Bayesian Approaches for Information Processing Pathway Maps

Abstract

Information Processing Pathway Maps (IPPMs) offer a scalable framework for formalizing the complex sequence of mathematical transformations applied to sensory stimuli. These maps chart the latency and cortical expression of computational steps, relying on statistical inference to link model outputs with observed neural activity. Traditionally, this mapping has relied on frequentist hypothesis testing. However, determining which of several competing computational models best explains neural data is a problem of model adjudication, arguably better suited to probabilistic inference. Here, we present a direct comparison between the established frequentist approach and a novel Bayesian framework for mapping cortical entrainment. While the Bayesian formulation retains the core strength of IPPMs -- generating explicit predictions of time-varying neural signals -- it fundamentally alters the selection criterion, shifting from rejecting a null hypothesis to quantifying the relative evidence for competing computational hypotheses. We evaluate the performance and interpretability of both approaches using an auditory neuroimaging dataset to reconstruct a known loudness-processing pathway. We discuss the implications of this shift for systems neuroscience, specifically regarding the handling of collinear models and the robust accumulation of evidence.