Postsynaptic mechanisms for the induction of long-term potentiation and long-term depression of synaptic transmission in CA1 pyramidal neurons of the hippocampus

Abstract

The studies described in this dissertation have attempted to address the cellular mechanisms of information storage by the brain. My work has focused primarily on the postsynaptic events that occur during and after induction of long-term potentiation (LTP) and long-term depression (LTD) at the Schaffer collateral-CA1 synapse of the hippocampus. I have explored various aspects of the role of postsynaptic Ca$^{2+}$ in the induction of LTP and LTD using both extracellular and whole-cell recording techniques, as well as fluorescence imaging of Ca$^{2+}$. I have also examined the possible role of modulation of dendritic K$^{+}$ channels in the induction of LTP.