Real-time tissue-equivalent measurement of individual clinical radiotherapy pulses
Fernanda C. Rodrigues-Machado, Katherine Szabo, Jingyi Bian, Simon Bernard, Tanner Connell, Shirin A. Enger, Lilian Childress, Jack C. Sankey
Abstract
We apply the precision tools of cavity-enhanced absorption sensing to clinical oncology, demonstrating a dosimeter paradigm in which a centimeter-scale volume of water serves as a tissue-equivalent sensing medium. Our proof-of-concept, all-optical scheme achieves real-time readout of clinical radiation pulses with a nominal single-pulse resolution of 90 μGy. This demonstration paves the way toward fiber-integrated, micron-scale devices for in situ universal absolute dosimetry during treatment.
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