SABRE Hyperpolarization of Unmodified Amino Acids in Partially Aqueous Media: L-[1-13C]-Valine as a Model System
Oksana A. Bondar, Thomas B. R. Robertson
Abstract
Hyperpolarization techniques enhance the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI), enabling detection of low concentration metabolites and dynamic processes. Signal Amplification by Reversible Exchange (SABRE) transfers spin polarization from parahydrogen without permanent chemical modification of the substrate. Here, we demonstrate SABRE-mediated 13C hyperpolarization of unmodified amino acids using L-[1- 13C]-valine as the primary model system and provide preliminary evidence of applicability to glycine. Signal enhancements exceeding 60-fold were observed on a 1.1 T benchtop NMR spectrometer. The dependence of polarization on parahydrogen bubbling time, solvent composition, and substrate-to-catalyst ratio was investigated.
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