Joint Near-Field Holotomography Reconstruction with a Phase-Guided Bregman TV Regularization

Abstract

Near-field holotomography combines coherent diffraction imaging with tomographic acquisition to recover the three-dimensional complex refractive index of a specimen. Since the measured diffraction intensities are generated by a nonlinear object transmission and wave propagation process, the resulting inverse problem is intrinsically nonlinear and ill-posed. We study a direct variational reconstruction framework based on a fully nonlinear wave propagation model that avoids both intermediate phase retrieval and linearization under the weak-object approximation. We analyze the forward operator in appropriate Banach spaces, establish its Fréchet differentiability, and derive explicit gradient expressions for variational reconstruction. To improve quantitative reconstruction of weak absorption features, we further develop a phase-guided Bregman TV regularization framework that exploits structural correlations between phase and absorption components. This enables multi-material reconstruction without imposing a globally fixed ratio between the two components. We perform numerical studies on synthetic phantoms and experimental data. The results demonstrate stable three-dimensional reconstructions and improved recovery of the absorption contrast compared to state-of-the-art methods.