An Evidence-Grounded Multi-Agent System for High-Level Bio-Robot Design

Abstract

In this paper, a bio-robot is an engineered living or biohybrid system in which living cells perform one or more core functions, such as sensing, information processing, actuation or output. We focus on systems whose cell-based functions are programmed by genetic circuits; physical movement is optional. Designing such a system requires translating application requirements into sensing, logic or memory, output, assembly, host and containment modules, while grounding each choice in traceable parts and evidence. We present micro_biorobot_agent, an offline multi-agent system built on Qwen3.5-27B. The system combines requirement analysis, module-specific retrieval, candidate assembly, conflict checking, local repair, independent review and validation over an integrated library of 23,762 records covering biological parts, measured combinations, literature-supported relationships and actuation evidence. Deterministic output checks align the final report with the retrieved part set and correct false gaps, unsupported part mentions and source-tracking errors. On two author-developed evaluation sets of 50 queries each, the system obtains mean overall scores of 7.35 and 8.04, the highest among the seven evaluated systems; on Scenario Design it exceeds the runner-up by 2.23 points. A 50-query paired ablation shows that the source-tracking check reduces false-gap incidents from 15 to 3, an 80% reduction, and increases source accuracy by 0.75 points. This paper reports the Qwen3.5-based v1 system and evaluates high-level design reports rather than experimentally validated circuits.