Roles of vortices and turbulent eddies in particle preferential concentration and deposition in the human respiratory tract

Abstract

Precise targeting of pharmaceutical aerosols is critical to the efficacy and safety of inhaled therapies. This study focused on the influences of vortices and turbulent eddies on preferential concentration and deposition of pharmaceutical aerosols within the human respiratory tract. By reconstructing a high-fidelity respiratory tract geometry spanning the nasal cavity down to sequential bronchi from computed tomography (CT) images and assigning physiologically realistic transient breathing profiles, an unsteady Reynolds-averaged Navier-Stokes (URANS) framework using the shear stress transport (SST) k-w turbulence model and a stress-blended eddy simulation (SBES) framework of human respiratory tract were built. Beyond flow field analyses, Vorono diagrams and a set of newly-defined spatial accuracy metrics were adopted to quantitatively characterize particle distributions and localized prediction discrepancies. Spectral analysis revealed that the SBES simulations adequately recovered the prominent Kolmogorov -5/3 inertial scaling law. Such turbulent motion induces pronounced radial turbulent dispersion, forming particle clusters with higher cluster fractal dimensions D> 1.2 on the mid-plane of the laryngopharynx. Spatial accuracy metrics uncovered a critical dual deficiency of the URANS model: globally over-smears near-wall deposition by roughly 20%, simultaneously fails to resolve most high-concentration `hotspots' (the top 5% local extrema). These findings highlighted that the numerical resolution of transient vortices and turbulent eddies constitutes an indispensable prerequisite for accurately predicting of particle transport and deposition in the human respiratory tract.