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Direct Asymmetric Photochemistry with Synthetic Chiral Light

Jason B. Greenwood, Letizia Fede, Daniel García González, Umberto Dellasette, Ross Anderson, Chris Sparling, Dave Townsend, Patricia Vindel-Zandbergen, David Ayuso, Valérie Blanchet, Bernard Pons, Andrès Ordóñez, Yann Mairesse

physics.chem-pharXiv:2609.12947

Abstract

Circularly polarized light has long been used to distinguish the two mirror images of chiral molecules. Recently, a conceptual breakthrough has predicted that a new form of optical fields - synthetic chiral light - could usher in an 'electric-dipole revolution' in chiroptical interactions. We report the first experimental evidence for this prediction in the optical domain, using a three-dimensional laser electric field synthesized to trace a chiral pattern. The ionization and fragmentation of chiral molecules was found to depend on both the molecular handedness, and the handedness and geometry of the synthetic chiral field. Supported by two theoretical models, our results demonstrate that synthetic chiral light can induce strong chiroptical interactions, opening new horizons for asymmetric photochemistry and chiral analysis.

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