Spatially Gated Diffusion for Localized Counterfactual Chest Radiograph Editing

Abstract

Editing a chest radiograph requires completing the requested change while preserving unrelated content. We study a latent diffusion editor with an instruction-independent source trajectory and an instruction-conditioned editing trajectory. A learned gate mixes their post-sampler candidates at each executed step, and a separate image-space mask composites the decoded proposal with the source. On 2,400 MIMIC-derived requests, 2,244 outputs met the joint target, preservation, quality, and coverage rubric (93.5%), and target completion was 97.4%. Joint validity exceeded a matched composition-only control by 1.7 percentage points (paired patient-cluster 95% interval, 0.6--2.8). At a fixed learned mask, the learned-gate proposal improved joint validity by 1.6 points (0.8--2.4); at a fixed learned proposal, the learned mask improved it by 2.6 points (1.7--3.5). Across three training seeds, mean joint validity was 93.5% with a 0.3-point sample standard deviation. A blinded 240-request assessment yielded adjudicated joint validity of 93.3% for the full editor and 91.7% for composition only. Protected-region mean absolute error decreased from 0.0190 in the raw proposal to 0.0075 after composition. These findings distinguish recurrent-gating effects on the proposal from preservation through final composition in the assessed cohort.