Simple model of neurogliovascular unit activity with noradrenaline leading force
Andrey Yu. Verisokin, Darya V. Verveyko, Alexey R. Brazhe, Stanislav V. Lagosha
Abstract
In this work we present a model of a neuroglivascular unit associated with a neuronal ensemble. We combine calcium dynamics in the astrocyte, the cascade of synthesis of arachidonic acid and its derivatives, as well as the activity of the network of inhibitory and excitatory neurons with changes in local blood flow. We add equations to the model for extracellular neurotransmitters such as GABA, glutamate, and norepinephrine. We show that the resulting model can exhibit different types of behavior, and also shows a significant connection between the functioning of the neural network and its supporting components.
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