Exact Solution of the Munoz-Eaton Model for Protein Folding
Abstract
A transfer-matrix formalism is introduced to evaluate exactly the partition function of the Munoz-Eaton model, relating the folding kinetics of proteins of known structure to their thermodynamics and topology. This technique can be used for a generic protein, for any choice of the energy and entropy parameters, and in principle allows the model to be used as a first tool to characterize the dynamics of a protein of known native state and equilibrium population. Applications to a β-hairpin and to protein CI-2, with comparisons to previous results, are also shown.
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