Bell Rate Model with Dynamic Disorder: Model and Its Application in the Receptor-ligand Forced Dissociation Experiments

Abstract

We extend the Bell forced dissociation rate model to take account into dynamic disorder. The motivation of the present work is from the recent forced dissociation experiments of the adhesive receptor-ligand complexes, in which some complexes were found to increase their mean lifetimes (catch bonds) when they are stretched by mechanical force, while the force increases beyond some thresholds their lifetimes decrease (slip bonds). Different from our previous model of force modulating dynamic disorder, in present work we allow that the projection of force onto the direction from the bound to the transition state of complex could be negative. Our quantitative description is based on a one-dimension diffusion-assisted reaction model. We find that, although the model can well describe the catch-slip transitions observed in the single bond P-selctin glycoprotein ligand 1(PSGL-1)-P- and L-selectin forced dissociation experiments, it might be physically unacceptable because the model predicts a slip-catch bond transitions when the conformational diffusion coefficient tends to zero.