A Precise Packing Sequence for Self-Assembled Convex Structures

Abstract

Molecular simulations of the self-assembly of cone-shaped particles with specific, attractive interactions are performed. Upon cooling from random initial conditions, we find that the cones self assemble into clusters and that clusters comprised of particular numbers of cones (e.g. 4 - 17, 20, 27, 32, 42) have a unique and precisely packed structure that is robust over a range of cone angles. These precise clusters form a sequence of structures at specific cluster sizes- a precise packing sequence - that for small sizes is identical to that observed in evaporation-driven assembly of colloidal spheres. We further show that this sequence is reproduced and extended in simulations of two simple models of spheres self-assembling from random initial conditions subject to certain convexity constraints. This sequence contains six of the most common virus capsid structures obtained in vivo including large chiral clusters, and a cluster that may correspond to several non-icosahedral, spherical virus capsid structures obtained in vivo. Our findings suggest this precise packing sequence results from free energy minimization subject to convexity constraints and is applicable to a broad range of assembly processes.