Denaturation of Heterogeneous DNA
D. Cule, T. Hwa
Abstract
The effect of heterogeneous sequence composition on the denaturation of double stranded DNA is investigated. The resulting pair-binding energy variation is found to have a negligible effect on the critical properties of the smooth second order melting transition in the simplest (Peyrard-Bishop) model. However, sequence heterogeneity is dramatically amplified upon adopting a more realistic treatment of the backbone stiffness. The model yields features of ``multi-step melting'' similar to those observed in experiments.
Create a lesson
Related papers
Real-Space renormalization for the drawups and drawdowns of stochastic trajectories: universality classes for diffusion processes and random walks via the scale function
Cecile Monthus
Stochastic synthesis and degradation of arbitrary diffusive processes
Denis Boyer, Gabriel Mercado-Vásquez
Critical amplitudes of the Baxter-Wu model from MCPA and Wolff simulations: free-exponent and fixed-exponent fits
Vyacheslav Mozolenko, Ian Pile, Lev Shchur
Capillary Coarsening Drives Re-entrant Statistical Transitions in Early Coffee-Ring Growth
Arundas Chandradasan, Dileep Mampallil
Maximum entropy explanation for the ubiquity of power-law mechanical responses
Sverre Holm
Thermodynamic Bethe Ansatz for the Toda chain from inverse scattering transform
Alberto Brollo