An Analytical Approach to the Protein Designability Problem
Edo L. Kussell, Eugene I. Shakhnovich
Abstract
We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a heirarchy of structures, from most to least designable, and show that this heirarchy depends on the potential that is used.
Create a lesson
Related papers
Designing tunable hyperuniformity in random organization through nonlocal noise
Yusheng Lei, Yuhan Peng, Ran Ni
Long-time Brownian dynamics of hard and sticky colloids by geometric projection
Rémi Martin, Sandrine Duluard, Céline Merlet
Statistical approach of random packing of polydisperse similar hyperspheres: with application to binomial and lognormal size distributions
H. J. H. Brouwers
Hydrated porous substrates modulate the spatiotemporal dynamics of bacterial turbulence
Zixiang Lin, Jin Zhu, Hongyi Bian et al.
Amplified transport variability in granular slope flows near the critical angle
Fumiaki Nakai, Yuto Sasaki
Topology Does Not Determine Defect Mobility in Active Polar Matter
Abhra Puitandy, Shradha Mishra