Estimating the proportion of false null hypotheses among a large number of independently tested hypotheses

Abstract

We consider the problem of estimating the number of false null hypotheses among a very large number of independently tested hypotheses, focusing on the situation in which the proportion of false null hypotheses is very small. We propose a family of methods for establishing lower $100(1-α)%$ confidence bounds for this proportion, based on the empirical distribution of the $p$-values of the tests. Methods in this family are then compared in terms of ability to consistently estimate the proportion by letting $α\to 0$ as the number of hypothesis tests increases and the proportion decreases. This work is motivated by a signal detection problem that occurs in astronomy.