Self-Organizing Approach for Finding Borders of DNA Coding Regions

Abstract

A self-organizing approach is proposed for gene finding based on the model of codon usage for coding regions and positional preference for noncoding regions. The symmetry between the direct and reverse coding regions is adopted for reducing the number of parameters. Without requiring prior training, parameters are estimated by iteration. By employing the window sliding technique and likelihood ratio, a very accurate segmentation is obtained.