Analytical study of the effect of recombination on evolution via DNA shuffling
Weiqun Peng, Herbert Levine, Terence Hwa, David A. Kessler
Abstract
We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in in vitro directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections.
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