A mathematical model of DNA degradation: Possible role of magnetic nanoparticles
V. N. Binhi
Abstract
A mathematical model of genome degradation is proposed that takes into account a variable rate of mutation and increasing number of cells in a developing human organism. The model explains known properties of cancer development, in particular, a synergism between different mutagens and an increased probability of cancer in the early years of life. An iteration equation is suggested that uses only a few model parameters and describes basic regularities observed in cancer onset. In the model context, relatively small chronic variations in the intracellular content of free radicals may markedly affect the probability of a cell to become a cancer cell. On the other hand, magnetic nanoparticles are shown to be an endogenous source of chronic magnetic exposure that increases the local concentration of free radicals. An enhanced level of leukaemia in early childhood is assumed to originate from magnetic nanoparticles located in hematopoietic stem cells.
Create a lesson
Related papers
The Motile-Units model: Interacting spins model of cell polarization and motility
Jonathan E. Ron, Nir S. Gov
Limits of Inferring Parametric Response from Single-Condition Trajectories inStochastic Reaction Networks
Quentin Thommen
Multiflagellarity facilitates bacterial upstream motility
Ran Tao, Nathaniel C. Esteves, Wanho Lee et al.
Protein eXplosion Imaging (PXI): Protein Structures from Laser-Driven Explosions
Alfredo Bellisario, Tomas André, Carl Caleman et al.
Multiscale retinal flow on a spherical cap of varying aperture
Chang Lin, Zilong Song, Bob Eisenberg et al.
Double-well potentials and crucial estimations in nonlinear dynamics of microtubules
Rama Gupta, Nicolina Pop, Dragana Ranković et al.