On the codon assignment of chain termination signals and the minimization of the effects of frameshift mutations
J. -L. Jestin, A. Kempf
Abstract
It has been suggested that the minimization of the probability for lethal mutations is a major constraint shaping the genetic code, with the finding that the genetic code is highly protective against transition mutations. Here, we show that recent data on polymerase-induced frameshifts provide a rationale for the codon assignment of chain termination signals (CTS).
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