A generalized model of mutation-selection balance with applications to aging
David Steinsaltz, Steven N. Evans, Kenneth W. Wachter
Abstract
A probability model is presented for the dynamics of mutation-selection balance in a haploid infinite-population infinite-sites setting sufficiently general to cover mutation-driven changes in full age-specific demographic schedules. The model accommodates epistatic as well as additive selective costs. Closed form characterizations are obtained for solutions in finite time, along with proofs of convergence to stationary distributions and a proof of the uniqueness of solutions in a restricted case. Examples are given of applications to the biodemography of aging, including instabilities in current formulations of mutation accumulation.
Create a lesson
Related papers
Evolving view on phylogenetic networks
Claudia Solis-Lemus
Keep on growing or change direction? Dependence of clonal plant survival on the probability of side-branching
Róbert Juhász, Beáta Oborny
A resident-traveller model for global aspects of vaccination
Julien Arino, P. van den Driessche
Sharp transitions between optimal therapy regimes reveal robust dosing strategies against drug-induced persistence
Einar Bjarki Gunnarsson
Spatial structure promotes coexistence, resilience, and synergy in microbial communities
Motasem ElGamel, Andrew Mugler
How timing and mode of selection shape ancestral genetic contributions
Juan Mardomingo-Sanz, Raphaël Tran-Thanh, Camille Coron et al.