Spectral Analysis of Protein-Protein Interactions in Drosophila melanogaster
Christel Kamp, Kim Christensen
Abstract
Within a case study on the protein-protein interaction network (PIN) of Drosophila melanogaster we investigate the relation between the network's spectral properties and its structural features such as the prevalence of specific subgraphs or duplicate nodes as a result of its evolutionary history. The discrete part of the spectral density shows fingerprints of the PIN's topological features including a preference for loop structures. Duplicate nodes are another prominent feature of PINs and we discuss their representation in the PIN's spectrum as well as their biological implications.
Create a lesson
Related papers
Artificial Intelligence-Assisted Systems Biology Reconstruction of Diabetic Bone Marrow Dysfunction
Paolo Madeddu
IMPPAT 3.0: An updated FAIR database of phytochemicals and formulations of Indian Medicinal plants
Shanmuga Priya Baskaran, Ajaya Kumar Sahoo, Priyotosh Sil et al.
Protocol for Discovering Convergent Molecular Networks across Multi-Omics Datasets Using Network Propagation
Charles O. Olwal, Declan M. Winters, Immy A. Ashley et al.
An interactive simulator for integrating biochemical models with experimental data
Herbert M. Sauro, Dan Nguyen, Long Nguyenle et al.
Large-deviations theory for growing chemical reaction networks
Praful Gagrani, Ignacio Madrid, Tetsuya J Kobayashi
Minimality in Reflexive and Stoichiometric Autocatalysis
Richard Golnik, Thomas Gatter, Wim Hordijk et al.