Active percolation analysis of pyramidal neurons of somatosensory cortex: A comparison of wildtype and p21H-ras^Val12 transgenic mice

Abstract

This article describes the investigation of morphological variations among two set of neuronal cells, namely a control group of wild type rat cells and a group of cells of a trangenic line. Special attention is given to sigular points in the neuronal structure, namely the branching points and extremities of the dendritic processes. The characterization of the spatial distribution of such points is obtained by using a recently reported morphological technique based on forced percolation and window-size compensation, which is particularly suited to the analysis of scattered points presenting several coexisting densities. Different dispersions were identified in our statistical analysis, suggesting that the transgenic line of neurons is characterized by a more pronounced morphological variation. A classification scheme based on a canonical discriminant function was also considered in order to identify the morphological differences.