Combinatorial on/off Model for Olfactory Coding

Abstract

We present a model for olfactory coding based on spatial representation of glomerular responses. In this model distinct odorants activate specific subsets of glomeruli, dependent upon the odorant's chemical identity and concentration. The glomerular response specificities are understood statistically, based on experimentally measured distributions of detection thresholds. A simple version of the model, in which glomerular responses are binary (the on/off model), allows us to account quantitatively for the following results of human/rodent olfactory psychophysics: 1) just noticeable differences in the perceived concentration of a single odor (Weber ratios) are dC/C ~ 0.04; 2) the number of simultaneously perceived odors can be as high as 12; 3) extensive lesions of the olfactory bulb do not lead to significant changes in detection or discrimination thresholds. We conclude that a combinatorial code based on a binary glomerular response is sufficient to account for the discrimination capacity of the mammalian olfactory system.