Periodic solutions of piecewise affine gene network models: the case of a negative feedback loop

Abstract

In this paper the existence and unicity of a stable periodic orbit is proven, for a class of piecewise affine differential equations in dimension 3 or more, provided their interaction structure is a negative feedback loop. It is also shown that the same systems converge toward a unique stable equilibrium point in dimension 2. This extends a theorem of Snoussi, which showed the existence of these orbits only. The considered class of equations is usually studied as a model of gene regulatory networks. It is not assumed that all decay rates are identical, which is biologically irrelevant, but has been done in the vast majority of previous studies. Our work relies on classical results about fixed points of monotone, concave operators acting on positive variables. Moreover, the used techniques are very likely to apply in more general contexts, opening directions for future work.