Proteomic nonlinear waves in networks of transcriptional regulators
Abstract
A chain of connected genes with activation-repression links is analysed. It is shown that for various promoter activity functions (parametrised by Hill coefficient) the equations describing the concentrations of transcription factors, are differential-difference KdV-type with perturbations. In the case of large Hill coefficient the proteomic signal along the gene network is given by a superposition of perturbed dark solitons of defocusing differential-difference mKdV equation. Biological implications are discussed.
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