How Compliant is Sepsis Treatment? An Expert-Guided Neuro-symbolic Pipeline for Generating Clinical Compliance Insights
Himanshu Tripathi, Kaushik Roy, Subash Neupane, Shahram Rahimi
Abstract
Verifying whether clinical care follows evidence-based protocols is a natural neuro-symbolic problem, yet the safety-critical setting defeats either paradigm alone. We present an expert-guided pipeline that constrains a large language model strictly to semantic normalization, mapping messy drug and microbiology strings onto a fixed clinical vocabulary, while a Sugeno fuzzy inference system reasons over the normalized events. The fuzzy layer encodes eight Surviving Sepsis Campaign bundle rules and replaces binary judgments with graded scores in [0,1]. Applied to 2,438 MIMIC-IV v3.1 sepsis episodes, it surfaces antibiotic timing as the most critical breakdown (mean 0.24, 13% within one hour), Hour-1 underperformance (mean 36.7%), a 51% elevated-lactate drop-off, and descriptive differences in ICU stay across compliance groups (3.8 versus 5.1 days).
Create a lesson
Related papers
MUSE: Benchmarking Large Vision-Language Models on Multi-Modal Understanding in Situated Education
Luyao Zhu, Xun Wei Yee, Wei Li et al.
Infinite-Parameter LLMs: Generating and Adapting Weights from Live Data
Jinli Hu, Ross M. Clarke, Yichuan Zhang et al.
Compositional Policy Violations: When Step-Level Compliance Fails In Agentic AI Workflows
Ashwini Kurady, Sri Sai Charith Grandhi, Rajesh Gupta et al.
CERA-MoA: Co-Evolving Routing Mechanisms with Continually Learning LLM Agents
Jiaxuan Jiang, Liyuan He, Zhixuan Fang
Version- and Scope-Aware Question Answering over Normative Documents: A Deployed System and an End-to-End Evaluation at Production Scale
Liuyin Wang, Shuaipeng Jin, Jiwei Shi et al.
Clueing up LLMs with Tool-Augmented Deductive Reasoning
Rebecca Ansell, Autumn Toney-Wails