Framework for Grounding Healthcare LLMs in a Causal Knowledge Graph: A Cardiovascular Example Pilot

Abstract

Large language models (LLMs) are increasingly proposed for healthcare decision support, but their evaluations still reward single-answer accuracy rather than reasoning about interventions, mechanisms, harms, evidence, and uncertainty. We propose a reproducible, graph-centered evaluation framework for intervention-oriented LLM behavior in healthcare and stress-test it in a cardiovascular pilot. The framework has four components: (i) a domain causal knowledge graph in which assertions are first-class, provenance-preserving nodes with stable identifiers; (ii) a scenario-conditioned subgraph extraction step that, given any clinical scenario, retrieves the relevant reified-assertion subgraph; (iii) four controlled grounding conditions that vary how the retrieved subgraph is composed into the model's context (ungrounded C1, knowledge-graph C2, causal-graph C3, integrated C4); and (iv) an automated scoring pipeline, anchored on assertion identifiers, that computes intervention accuracy, and other evaluation measures on a single pass. To test the framework, we built a category-balanced scenario generator across eight reasoning failure modes and instantiated it on a cardiovascular graph. The metric panel discriminates conditions along interpretable, non-redundant axes: C4 obtains the strongest causal edge F1 (0.838), adverse-effect F1 (0.833), evidence accuracy (0.738), and unsupported claim rate (0.114), while C1 obtains the highest raw intervention accuracy (0.948) with no measurable causal or evidential grounding.