Lengthscales and Cooperativity in DNA Bubble Formation
Z. Rapti, A. Smerzi, K. Ø. Rasmussen, A. R. Bishop
Abstract
It appears that thermally activated DNA bubbles of different sizes play central roles in important genetic processes. Here we show that the probability for the formation of such bubbles is regulated by the number of soft AT pairs in specific regions with lengths which at physiological temperatures are of the order of (but not equal to) the size of the bubble. The analysis is based on the Peyrard- Bishop-Dauxois model, whose equilibrium statistical properties have been accurately calculated here with a transfer integral approach.
Create a lesson
Related papers
Nonparametric multiscale modeling of boundary lubrication: hexadecane in highly pressurized gold asperity contacts
Hannes Holey, Michael Moseler, Peter Gumbsch et al.
Asymmetric Ions in Solution are Similar to Active Brownian Particles
Setare Mostajabi Sarhangi, Dmitry V. Matyushov
Influence of twist direction and large deformation on soft material torsional contact
Yucai Hu, Pengfei Li, Michele Ciavarella et al.
Phase transitions and microphases in elastomers. II. Anisotropy-driven morphologies
Manu Mannattil, David Andelman, Haim Diamant
Comparing non-local granular fluid continuum models for silo discharge: Toward clogging prediction
Y. Zhou, Y. Wang, M. Li et al.
Residual semi-crystalline particles released during enzymatic degradation of plastics
Michael Schindler, Ludwik Leibler