Efficiency of initiating cell adhesion in hydrodynamic flow
C. Korn, U. S. Schwarz
Abstract
We theoretically investigate the efficiency of initial binding between a receptor-coated sphere and a ligand-coated wall in linear shear flow. The mean first passage time for binding decreases monotonically with increasing shear rate. Above a saturation threshold of the order of a few 100 receptor patches, the binding efficiency is enhanced only weakly by increasing their number and size, but strongly by increasing their height. This explains why white blood cells in the blood flow adhere through receptor patches localized to the tips of microvilli, and why malaria-infected red blood cells form elevated receptor patches (knobs).
Create a lesson
Related papers
Nonparametric multiscale modeling of boundary lubrication: hexadecane in highly pressurized gold asperity contacts
Hannes Holey, Michael Moseler, Peter Gumbsch et al.
Asymmetric Ions in Solution are Similar to Active Brownian Particles
Setare Mostajabi Sarhangi, Dmitry V. Matyushov
Influence of twist direction and large deformation on soft material torsional contact
Yucai Hu, Pengfei Li, Michele Ciavarella et al.
Phase transitions and microphases in elastomers. II. Anisotropy-driven morphologies
Manu Mannattil, David Andelman, Haim Diamant
Comparing non-local granular fluid continuum models for silo discharge: Toward clogging prediction
Y. Zhou, Y. Wang, M. Li et al.
Residual semi-crystalline particles released during enzymatic degradation of plastics
Michael Schindler, Ludwik Leibler