Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology
N. Fertig, A. Tilke, R. H. Blick, J. P. Kotthaus, J. C. Behrends, G. ten Bruggencate
Abstract
We investigate the microscopic contact of a cell/semiconductor hybrid. The semiconductor is nanostructured with the aim of single channel recording of ion channels in cell membranes. This approach will overcome many limitations of the classical patch-clamp technique. The integration of silicon-based devices 'on-chip' promises novel types of experiments on single ion channels.
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